Endocrine Abstracts

Introduction: 17 alpha-hydroxylase deficiency (17OHD) is a rare autosomal recessive disease caused by mutations in the CYP17A gene, representing 1% of cases of Congenital Adrenal Hyperplasia (CAH). The accumulation of mineralocorticoids and the glucocorticoid effect of corticosterone induce high blood pressure (HBP) and hypokalemia.Clinical Case: A 44 year-old female reporting HBP since the age of 20 years and without chronic medication, presented at the...

Introduction: The update of 2015 American Thyroid Association (ATA) guidelines recommend that radioactive iodine (RAI) ablation therapy should be used in line with patients’ risk stratification. However, there is no consensus on benefits of post-operative RAI ablation in patients with low risk differentiated thyroid cancer (DTC). The aim of this study is to compare the outcomes of patients with low risk DCT submitted to RAI ablation with those who were not.<p class="a...

Background: To minimize potential harm from overtreatment of low-risk thyroid cancers, the 2015 American Thyroid Association (ATA) Guidelines recommend that radioactive iodine (RAI) ablation should not be routinely used in low-risk differentiated thyroid carcinoma (DTC). The present study aims to evaluate trends in RAI therapy in a tertiary center after the update of these Guidelines.Methods: Data from patients followed in a tertiary center with low-risk...

Introduction: Graves orbitopathy is the major extrathyroidal manifestation of Graves Disease (GD). The approach depends on its clinical activity and severity. Treatment and referral to specialized centers, with Endocrinology and Ophthalmology, has a strong impact on the prognosis of Graves’ Disease (GD) and GO.Cases report: We report four cases of DG with OG. Their characteristics and clinical evolution are shown in Table 1.<table boarder="1" ce...

Introduction: A third of pituitary adenomas are non-functioning. Classification depends on adenohypophyseal hormones expression and transcription factors.Aim: Characterize silent pituitary macroadenomas cases regarding their clinical data, treatment, histopathology and prognosis.Methods: We revised clinical process of patients followed in CHULC. Cases with non-access to clinical follow-up registries or exams were excluded.<p cl...

IntroductionMaturity Onset Diabetes of the Young (MODY) affects 1–2% of diabetic patients. Subtype 5 (HNF1β mutation) is rare (~1% of all MODY subtypes) and extra-pancreatic manifestations are often present (chronic kidney disease (CKD), liver disease and/or genitourinary malformations).AimTo report and review confirmed MODY 5 cases in an Endocrinology Department.Meth...

IntroductionHypocalcaemia is a complication of total thyroidectomy (TT) and may be more frequent in patients with Graves’ disease. The reason for this increased risk is unclear and its occurrence has been associated with: ophthalmopathy severity, preoperative calcaemia and reimplantation of parathyroid glands.ObjectivesTo evaluate the risk factors for transient hypocalcaemia (TH) and definitive hypoparat...

Introduction: Parathyroid adenoma is the most frequent cause of primary hyperparathyroidism (PHPT). In recent years minimally invasive surgical techniques have challenged the traditional bilateral neck exploration. There are different imaging techniques for preoperative location of parathyroid adenomas. In this study the authors review the role of Doppler ultrasound focusing on its safety, availability and affordability.Aim: To evaluate the role of Doppl...

IntroductionDiabetic foot is one of the most devastating of chronic complications of diabetes mellitus (DM) and is responsible for about 25% of hospitalizations. Worldwide, the diabetic foot represents the main cause of non-traumatic lower limb amputation.Aim of the studyIdentification of risk factors for foot amputation among in patients hospitalized for diabetic foot in a tertiary public hospital in Portuga...